This effect may be related to dose and duration of treatment. Female rats treated with ethambutol hydrochloride displayed slight but. Ethambutol hydrochloride is a commonly used firstline antituberculous agent. R2,21,2ethanediyldiiminobis1butanol dihydrochloride, levoethambutol hydrochloride empirical formula hill notation. Sds of ethambutol dihydrochloride, safety data sheets, cas. Ethambutol emb is a widely used agent in the treatment of tubercular and nontubercular mycobacterial disease. Ethambutol hydrochloride is an oral chemotherapeutic agent which is. Ethambutol has been associated with optic neuritis characterized by central and peripheral scotomas, decreases in visual acuity, and constriction of visual fields. Ethambutol is also contraindicated in patients who are unable to appreciate and report visual side effects or changes in vision i. Jun 17, 2019 ethambutol hydrochloride is an antituberculous antitb prescription medicine approved by the u. Ethambutol fda prescribing information, side effects and. It is generally prescribed in the combination with isoniazid, rifampicin, or pyrazinamide. Ethambutol is a commonly used antituberculous medications.
Ethambutol has poor csf penetration, even in the setting of inflammation. Ethambutol hydrochloride drug bnf content published by nice. Ethambutol is used to treat tuberculosis, often in combination with other medications. In particular, ethambutol should be used with caution in children until they are at least 5 years old and capable of reporting symptomatic visual changes accurately. Ethambutol is used with other medications to treat tuberculosis tb. For research use only, not for human or veterinary use.
It may also be used to treat mycobacterium avium complex, and mycobacterium kansasii. Ethambutol hydrochloride has been shown to be teratogenic in pregnant mice and rabbits when given in high doses. It is also used as part of a combination regimen in the therapy of mycobacterium avium complex infections in patients with or without concomitant infection with hiv 1. Ethambutol hydrochloride drug bnfc content published by nice. Optic neuropathy including optic neuritis or retrobulbar neuritis occurring in association with ethambutol therapy may be characterized by one or more of the following events. Ethambutol hydrochloride is a white, crystalline powder, it is freely soluble in water. May 01, 2019 ethambutol hcl is contraindicated in patients who are unable to appreciate and report visual side effects or changes in vision e. Health ethambutol hydrochloride is contraindicated in patients who are known to be hypersensitive to this drug. This product is assumed to be combustible at high temperatures combustion products. Fire and explosion assume that this product is capable of sustaining combustion. Identification of the substancemixture and of the companyundertaking product name. The drug is regarded as the least toxic of the firstline antituberculosis drugs, with a low incidence of ocular toxicity. Treatment of active clinical tuberculosis tb in conjunction with other antituberculosis agents. Ethambutol hcl is contraindicated in patients who are unable to appreciate and report visual side effects or changes in vision e.
Ethambutol hydrochloride monograph for professionals. Synonyms ethambutol hcl unii qe4vw5fo07 cas number 1070117 weight average. Ethambutol hydrochloride is removed by hemodialysis and peritoneal dialysis. Myambutol ethambutol hcl tablets description microorganisms. This works best when taken with food or milk to prevent. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy.
The results of a study of coadministration of myambutol 50mgkg with an aluminum hydroxide containing antacid to patients with tuberculosis showed a reduction of mean serum concentrations and urinary excretion of ethambutol of approximately 20% and %, respectively, suggesting that the oral absorption of ethambutol may be reduced by these. Ethambutol hydrochloride is used in combination with at least one other antitb medicine. When pregnant mice or rabbits were treated with high doses of ethambutol hydrochloride, fetal mortality was slightly but not significantly p0. Find patient medical information for ethambutol hcl bulk on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. It needs to be detected early and medication stopped promptly to. Sigmaaldrich offers a number of ethambutol hydrochloride products. Ethambutol is a first line but adjunctive antituberculosis medication which is used only in combination with other agents such as isoniazid and rifampin. In hong kong, the usual daily dosage is 15mgkg for adults and children, therefore, ethambutol ocular toxicity is not commonly seen in hong kong. Female rats treated with ethambutol hydrochloride displayed slight but insignificant p0. Patients who cannot understand warnings about visual sideeffects should, if possible, be given an alternative drug. Ethambutol is used to treat tuberculosis tb, and is.
Food and drug administration fda for the treatment of active tuberculosis tb of the lungs. Ethambutol is an antibiotic and works by stopping the growth of bacteria. Antitubercular, antileprotic pregnancy risk category b action. Rifampicin, isoniazid, pyrazinamide and ethambutol hydrochloride tablets should be kept in a tightly closed container, protected from light.
Ethambutol hydrochloride tablets, usp only description ethambutol hydrochloride is an oral chemotherapeutic agent which is specifically effective against actively growing microorganisms of the genus mycobacterium, including m. It should be taken with other medicines to prevent the spread of infection. Ethambutol is used to treat tuberculosis tb, and is usually given together with at least one other. Strength in the current who model list of essential medicines. Ethambutol hydrochloride is an antituberculous antitb prescription medicine approved by the u.
Myambutol ethambutol hydrochloride dose, indications. Other companies are charging thousands of dollars to set up accounts and. Ethambutol hydrochloride drug bnfc content published. It is usually given in combination with other tuberculosis medications, such as isoniazid, rifampicin and pyrazinamide. Emits toxic fumes of nitric oxides and hydrochloride. First aid measures material safety data sheet material ethambutol hydrochloride tablets usp 100 mg and 400 mg manufacturer lupin limited mumbai 400 098 india. Ethambutol side effects, dosage, interactions drugs. Fire fighting measures flammability of the product.
Ethambutol hydrochloride is an oral chemotherapeutic agent which is specifically effective against actively growing microorganisms of the genus mycobacterium, including m. Myambutol 100 and 400 mg tablets contain the following inactive ingredients. Jan 22, 2020 available as ethambutol hydrochloride. Other companies are charging thousands of dollars to set up accounts and give you access to their msds online. Ethambutol is administered, easily absorbed well, and bacteriostatic against m. Ethambutol hydrochloride safety data sheet according to regulation ec no.
Although rare, ocular toxicity in the form of optic neuritis most commonly retrobulbar neuritis has been well documented since its first use in the 1960s. Any symptoms of vision problem should be reported to the doctor. It is usually part of a wider treatment of drugs that include rifampicin, pyrazinamide, and isoniazid. This medication may also be used to treat an infection known as mac mycobacterium avium complex. Myambutol ethambutol hydrochloride is an oral chemotherapeutic agent which is specifically effective against actively growing microorganisms of the genus mycobacterium, including m. Ethambutol is an antimycobacterial agent that is most commonly used in combination with other drugs in the treatment of tuberculosis 1. Ethambutol hydrochloride is an antitubercular agent that inhibits the transfer of mycolic acids into the cell wall of the tubercle bacillus. Ethambutol hydrochloride uses, side effects aidsinfo. Ethambutol is readily absorbed after oral administration and this absorption is not significantly impaired by food. Ethambutol hcl may produce decreases in visual acuity which appear to be due to optic neuritis.
Toxic by inhalation, in contact w ith skin and if swallowed. Ethambutol hydrochloride drug bnf content published. Ethambutol hcl is an antibiotic which is used for the treatment of tuberculosis. Ethambutol hydrochloride fda label tablet film coated. Ethambutol 800 mg tablet uses, dosage, side effects.
Myambutol may produce decreases in visual acuity, including irreversible blindness, which appear to be due to optic neuritis. Ethambutol hydrochloride is a white, crystalline powder. Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database. Ethambutol is an antibiotic that prevents growth of the tuberculous bacteria in the body. Calculate the quantity, in mg, of ethambutol hydrochloride c 10 h 24 n 2 o 2 hcl present in the portion of tablets taken by the formula. Ethambutol therapy has been associated with minor, transient and asymptomatic elevations in serum aminotransferase levels, but is a rare cause of clinically apparent acute liver injury.
Nov 09, 2018 ethambutol is an antibiotic that prevents growth of the tuberculous bacteria in the body. Material safety data sheet of ethambutol hydrochloride. Ethambutol 800 mg tablet is an antitubercular medicine which helps to treat tuberculosis and reduces the spread of infection. Ethambutol hydrochloride is a bacteriostatic antimycobacterial drug used to treat tuberculosis. Ethambutol emb, e is a medication primarily used to treat tuberculosis. Ethambutol fda prescribing information, side effects and uses. After a single dose of 25mgkg body weight, within 4 hours peak plasma concentrations of up to 5. Nov 27, 2019 ethambutol hydrochloride is an oral chemotherapeutic agent which is specifically effective against actively growing microorganisms of the genus mycobacterium, including m. Sep 08, 2014 register now and get a free online msds binder.